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biomedical Multimodal combining fMRI, sMRI, EGG and so on series 2

Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion

Amplitude of Low Frequency Fluctuations (ALFF) and fractional Amplitude of Low Frequency Fluctuations (f/ALFF) are neuroimaging methods used to measure spontaneous fluctuations in BOLD-fMRI signal intensity for a given region in the resting brain. 

Result

GM and FA maps demonstrate more consistent patterns across cognitive domains (r > 0.6), while fALFF maps exhibit more variance (r < 0.5 but still significant) and are more sensitive to domain differences.

Method

multimodal canonical correlation analysis with reference plus joint independent component analysis(MCCAR+jICA).

Reference:

https://www.nature.com/articles/s41467-018-05432-w
https://en.wikipedia.org/wiki/Amplitude_of_low_frequency_fluctuations#:~:text=Amplitude%20of%20Low%20Frequency%20Fluctuations%20(ALFF)%20and%20fractional%20Amplitude%20of,region%20in%20the%20resting%20brain.

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